Vitamin K and Fractures - NBI (2024)

Akiyama N, Miyazawa K, Kanda Y, et al. Multicenter phase II trial of vitamin K2 monotherapy and vitamin K2 plus 1[alpha]-hydroxyvitamin D3 combination therapy for low-risk myelodysplastic syndromes. Leukemia Research. 2010;34(9):1151-1157. [Article]

Asakura H, Myou S, Ontachi Y. Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency. Osteoporos Int. 2001;12(12):996-1000. [Article]

co*ckayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S, Torgerson DJ. Vitamin K and the Prevention of Fractures: Systematic Review and Meta-analysis of Randomized Controlled Trials. Arch Intern Med. 2006;166(12):1256-1261. [Article]

Conly J, Stein K. Reduction of vitamin K2 concentrations in human liver associated with the use of broad spectrum antimicrobials. Clin Invest Med. 1994;17(6):531-539. [Article]

Ferland G, Sadowski JA, O’Brien ME. Dietary induced subclinical vitamin K deficiency in normal human subjects. J Clin Invest. 1993;91(4):1761-1768. [Article]

Hodges SJ, Pilkington MJ, Shearer MJ, Bitensky L, Chayen J. Age-related changes in the circulating levels of congeners of vitamin K2, menaquinone-7 and menaquinone-8. Clin Sci (Lond). 1990;78(1):63-66. [Article]

Ide Y, Zhang H, Hamajima H, et al. Inhibition of matrix metalloproteinase expression by menatetrenone, a vitamin K2 analogue. Oncol Rep. 2009;22(3):599-604. [Article]

Iketani T, Kiriike N, Murray, et al. Effect of menatetrenone (vitamin K2) treatment on bone loss in patients with anorexia nervosa. Psychiatry Res. 2003;117(3):259-269. [Article]

Inoue T, Sugiyama T, Matsubara T, Kawai S, Furukawa S. Inverse correlation between the changes of lumbar bone mineral density and serum undercarboxylated osteocalcin after vitamin K2 (menatetrenone) treatment in children treated with glucocorticoid and alfacalcidol. Endocrine journal. 2001;48(1):11-18. [Article]

Institute of Medicine (U.S.). Panel on Macronutrients., Institute of Medicine (U.S.). Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Washington, D.C.: National Academy Press;2001. [Article]

Iwamoto I, Kosha S, Noguchi S-i. A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-progestin therapy. Maturitas. 1999;31(2):161-164. [Article]

Iwamoto J, Matsumoto H, Takeda T, Sato Y, Yeh J. Effects of Vitamin K2 on Cortical and Cancellous Bone Mass, Cortical Osteocyte and Lacunar System, and Porosity in Sciatic Neurectomized Rats. Calcif Tissue Int. 2010;87(3):254-262. [Article]

Iwamoto J, Seki A, Sato Y, Matsumoto H, Tadeda T, Yeh J. Vitamin K2 Promotes Bone Healing in a Rat Femoral Osteotomy Model with or without Glucocorticoid Treatment. Calcif Tissue Int. 2010;86(3):234-241. [Article]

Iwasaki Y, Yamato H, Murayama H, et al. Menatetrenone prevents osteoblast dysfunction in unilateral sciatic neurectomized rats. Japanese journal of pharmacology. 2002;90(1):88-93. [Article]

Jiang Y, Zhang Z-L, Zhang Z-L, et al. Menatetrenone versus alfacalcidol in the treatment of Chinese postmenopausal women with osteoporosis: a multicenter, randomized, double-blinded, double-dummy, positive drug-controlled clinical trial. Clinical Interventions in Aging. 2014;9:121-127. [Article]

McKeown NM, Jacques PF, Gundberg CM, et al. Dietary and nondietary determinants of vitamin K biochemical measures in men and women. J Nutr. 2002;132(6):1329-1334. [Article]

Miyazawa K, Nishimaki J, Ohyashiki K, et al. Vitamin K2 therapy for myelodysplastic syndromes (MDS) and post-MDS acute myeloid leukemia: information through a questionnaire survey of multi-center pilot studies in Japan. Leukemia. 2000;14(6):1156-1157. [Article]

Nishiguchi S, Shimoi S, Kurooka H. Randomized pilot trial of vitamin K2 for bone loss in patients with primary biliary cirrhosis. Journal of Hepatology. 2001;35(4):543-545. [Article]

Onodera K, Takahashi A, Sakurada S, Okano Y. Effects of phenytoin and/or vitamin K2 (menatetrenone) on bone mineral density in the tibiae of growing rats. Life Sciences. 2002;70(13):1533-1542. [Article]

Purwosunu Y, Muharram, Rachman IA, Reksoprodjo S, Sekizawa A. Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia. J Obstet Gynaecol Res. 2006;32(2):230-234. [Article]

Sasaki N, Kusano E, Takahashi H, et al. Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG). Journal of bone and mineral metabolism. 2005;23(1):41-47. [Article]

Sasaki N, Kusano E, Takahashi H, et al. Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG). Journal of bone and mineral metabolism. 2005;23(1):41-47. [Article]

Sato Y, Honda Y, Kuno H, Oizumi K. Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients. Bone. 1998;23(3):291-296. [Article]

Schurgers LJ, Teunissen KJF, Hamulyak K, Knapen MHJ, Vik H, Vermeer C. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007;109(8):3279-3283. [Article]

Shikano K, Kaneko K, Kawazoe M, Kaburaki M, Hasunuma T, Kawai S. Efficacy of Vitamin K2 for Glucocorticoid-induced Osteoporosis in Patients with Systemic Autoimmune Diseases. Internal Medicine. 2016;55(15):1997-2003. [Article]

Shiomi S, Nishiguchi S, Kubo S. Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver. The American Journal of Gastroenterology. 2002;97(4):978-981. [Article]

Shiraki M, Shiraki Y, Aoki C, Miura M. Vitamin K2 (Menatetrenone) Effectively Prevents Fractures and Sustains Lumbar Bone Mineral Density in Osteoporosis. Journal of Bone and Mineral Research. 2000;15(3):515-522. [Article]

Somekawa Y, Chigughi M, Harada M, Ishibashi T. Use of vitamin K2 (menatetrenone) and 1,25-dihydroxyvitamin D3 in the prevention of bone loss induced by leuprolide. J Clin Endocrinol Metab. 1999;84(8):2700-2704. [Article]

Sugiyama T, Tanaka H, Kawai S. Clinical vignette. Vitamin K plus vitamin D treatment of bone problems in a child with skeletal unloading. J Bone Miner Res. 1999;14(8):1466-1467. [Article]

Takami A, Asakura H, Nakao S. Menatetrenone, a vitamin K2 analog, ameliorates cytopenia in patients with refractory anemia of myelodysplastic syndrome. Ann Hematol. 2002;81(1):16-19. [Article]

Ushiroyama T, Ikeda A, Ueki M. Effect of continuous combined therapy with vitamin K2 and vitamin D3 on bone mineral density and coagulofibrinolysis function in postmenopausal women. Maturitas. 2002;41(3):211-221. [Article]

Yasui T, Miyatani Y, Tomita J. Effect of vitamin K2 treatment on carboxylation of osteocalcin in early postmenopausal women. Gynecological Endocrinology. 2006;22(8):455-459. [Article]

Yonemura K, f*ckasawa H, Fujigaki Y, Hishida A. Protective effect of vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine. Am J Kidney Dis. 2004;43(1):53-60. [Article]

Yonemura K, f*ckasawa H, Fujigaki Y, Hishida A. Protective effect of vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine. Am J Kidney Dis. 2004;43(1):53-60. [Article]

Yonemura K, Kimura M, Miyaji T, Hishida A. Short-term effect of vitamin K administration on prednisolone-induced loss of bone mineral density in patients with chronic glomerulonephritis. Calcified tissue international. 2000;66(2):123-128. [Article]

Vitamin K and Fractures - NBI (2024)

FAQs

Vitamin K and Fractures - NBI? ›

Research shows that specific forms of vitamin K help promote healthy platelet and blood production, grow stronger bones and decrease fractures, reduce markers of inflammation and promotes connective tissue (collagen) production, making it helpful in tissues throughout the entire body.

What is the effect of vitamin K on bone mineral density and fracture risk in adults systematic review and meta analysis? ›

For the BMD, a meta-analysis of the pooled effect of interventional studies suggested a non-significant association between the use of VK and improvement in femoral BMD (CI 95%, p = 0.08 [-0.03-0.20]). Conclusion: VK decreases general fracture risk, and it can be an option to counter bone loss disorders.

Does vitamin K help heal broken bones? ›

Some clinical observations (Bouckaert, A., and Hart Kliniek, H., personal communication) and preliminary experiments (Bouckaert, J. H., and Oyaert, W., personal communication) indicated that vitamin K had a real effect on all collagen tissues and especially bone tissue.

What is the relation between vitamin K intake and risk of bone fractures? ›

Vitamin K, Bone Mineral Density (BMD), and Fractures. Most studies find that low serum K1 concentrations, high levels of undercarboxylated osteocalcin (ucOC), and low dietary intake of both K1 and K2 are associated with a higher risk of fracture.

Does vitamin K2 increase bone density? ›

Human trials have shown that daily intake of 45 mg of vitamin K2 (MK-4) maintains or increases bone density and cuts the risk of fractures. Other vitamins and minerals, including calcium and vitamin D3, also support bone health, and help maximize vitamin K2's benefits.

What is the role of vitamin K in bone remodeling and osteoporosis? ›

Vitamin K prevents bone resorption via several mechanisms. It prevents osteoclast formation either directly or indirectly; that is, it could interfere with the expression of RANKL and upregulates the expression of OPG on osteoclast precursors.

What does vitamin K do for bones? ›

The human intervention studies have demonstrated that vitamin K can not only increase bone mineral density in osteoporotic people but also actually reduce fracture rates. Further, there is evidence in human intervention studies that vitamins K and D, a classic in bone metabolism, works synergistically on bone density.

Who should not take vitamin K2? ›

People with a rare metabolic condition called Glucose-6-phosphate dehydrogenase (G6PD) deficiency should avoid vitamin K. People who take warfarin (Coumadin) should not take vitamin K (see “Possible Interactions”). People who are receiving dialysis for kidney diseases can have harmful effects from too much vitamin K.

What heals broken bones the fastest? ›

In particular, calcium, vitamin D and protein will be important during the bone healing process, so be sure you're focusing on food sources rich in these nutrients, including dark, leafy greens, broccoli, fish, meat, yogurt, nuts and seeds.

What is the best supplement to heal bone fracture? ›

ZINC. Some 200 enzymes require zinc for their functioning. Many of these functions involve cell proliferation. Zinc supplementation aids in callus formation, enhances bone protein production, and thus stimulates fracture healing.

How much K2 should I take daily for osteoporosis? ›

Vitamin K2 MK7 dosage recommendation is 150 to 180 µg per day. This is based on the dosage used in most recent research studies. Recommended daily dosage for Vitamin K2 MK4 is 45 mg in Asia and Japan. Other jurisdictions do not provide guidance.

What foods are high in K2? ›

Dietary sources of vitamin K-2 include:
  • natto, a traditional Japanese dish of fermented soybeans.
  • sauerkraut.
  • dairy products, especially hard cheeses.
  • liver and other organ meats.
  • beef.
  • pork.
  • egg yolks.
  • chicken.

What happens if you take vitamin K2 everyday? ›

Some early research has shown that vitamin K2 may be more effective at clearing out calcium than vitamin K1. One study found that people who took in at least 32 micrograms per day of vitamin K2 in their diet were 50% less likely to die from heart disease related to hardened arteries.

What happens if you take too much vitamin K2? ›

Side effects of vitamin K excess include enlarged liver, paleness, increased sweating, shortness of breath, muscle stiffness, edema, irregular breathing, decreased movement or activity, swollen eyelids, or red skin.

Is 45 mg of K2 too much? ›

Vitamin K1 10 mg daily and vitamin K2 45 mg daily have been safely used for up to 2 years. It's usually well-tolerated, but some people may have an upset stomach or diarrhea.

What is the effect of vitamin K on bone mineral density a meta analysis of randomized controlled trials? ›

Vitamin K supplementation was shown to be efficacious in increasing BMD at the lumbar spine but not the femoral neck. The weighted mean difference (WMD) in BMD absolute change was 21.60 mg/cm(2) [95% confidence interval (CI) 3.63, 39.56] at the lumbar spine and 0.25 mg/cm(2) (95% CI -2.64, 3.14) at the femoral neck.

How does vitamin K increase bone density? ›

Studies indicate that vitamin K works directly on VKDPs such as osteocalcin and matrix Gla protein (MGP) to promote bone growth by increasing mineral deposition. The protective effects of vitamin K can be mediated by regulating relevant transcription factors and proteins through different signaling pathways.

Should I take vitamin K if I have osteoporosis? ›

Giving extra vitamin K to this population to correct their body stores, in addition to their regular treatment for post-menopausal osteoporosis, may further improve bone density and fracture risk.

How much vitamin K should I take for osteoporosis? ›

Vitamin K2 MK7 dosage recommendation is 150 to 180 µg per day. This is based on the dosage used in most recent research studies. Recommended daily dosage for Vitamin K2 MK4 is 45 mg in Asia and Japan. Other jurisdictions do not provide guidance.

Top Articles
Latest Posts
Article information

Author: Margart Wisoky

Last Updated:

Views: 6339

Rating: 4.8 / 5 (78 voted)

Reviews: 85% of readers found this page helpful

Author information

Name: Margart Wisoky

Birthday: 1993-05-13

Address: 2113 Abernathy Knoll, New Tamerafurt, CT 66893-2169

Phone: +25815234346805

Job: Central Developer

Hobby: Machining, Pottery, Rafting, Cosplaying, Jogging, Taekwondo, Scouting

Introduction: My name is Margart Wisoky, I am a gorgeous, shiny, successful, beautiful, adventurous, excited, pleasant person who loves writing and wants to share my knowledge and understanding with you.