Tea and Coffee Influence Disease Risk via DNA Methylation (2024)

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Tea and Coffee Influence Disease Risk via DNA Methylation? ›

Linking DNA Methylation Alterations to Coffee and Tea Consumption. Epigenetics can mediate the effects of dietary and lifestyle factors on disease onset, and two previous epigenome-wide association studies (EWAS) reported the association of DNA methylation status at certain CpGs

These findings, combined with those of earlier EWAS, indicate that coffee intake alters PHGDH gene expression and liver function by altering the methylation of cg14476101.

In the past decade, the epigenetic effects of coffee ingredients have been revealed, whereby coffee is able to impact the epigenome by modulating DNA methylation/demethylation, histone modifications, and ncRNA expression (Table 1), and potentially linked to the development of various human pathological conditions.

Caffeine prevents the binding of intercalating small molecules to DNA by forming hetero-association complexes with the molecules. For example, caffeine has been shown to displace fluorescent intercalators such as EBr, propidium iodide, and 7-aminoactinomycin D from genomic DNA previously stained with these dyes.

What Not to Eat for Methylation Support. The following article focuses on what not to eat to promote methylation support. Below, we will demonstrate what not to eat to improve DNA methylation including charred foods, added sugars, artificial sweeteners, hydrogenated fats, alcohol, and folic acid fortified foods.

Caffeine potentiates the mutagenic and lethal effects of genotoxic agents. It is thought that this is due, at least in some organisms, to inhibition of DNA repair.

Interestingly, they noted that high intake of green vegetables and folate was associated with lower DNA methylation, expressed as less than two genes methylated [51].

Fatigue is perhaps the most common symptom of problems with methylation. Other symptoms or conditions can include: Anxiety. Depression.

Chronic social stress induces DNA methylation changes at an evolutionary conserved intergenic region in chromosome X.

How does coffee strengthen your DNA? ›

Chlorogenic acid, one of the main components of coffee, is a powerful antioxidant that can inhibit DNA damage from free radicals. It protects our body against impaired cellular damage and lowers the risk of cancer. Further studies will be necessary to verify such results.

The environmental factors that can promote epigenetic mutations in humans are similar to known risk factors for cancer, including diet, lifestyle, and exposure to toxic substances.

Researchers at Northwestern University released a study that shows coffee drinkers who prefer the bitter taste of black coffee have a genetic variant that also reflects faster caffeine metabolism.

Caffeine inhibits DNA repair and induces growth arrest but protects against apoptosis.

Results. Caffeine inhibited collagen biosynthesis in a dose-dependent manner. The mechanism of this process was found at the level of prolidase activity. Caffeine significantly inhibited the enzyme activity.

While the biggest risk factors in developing mouth and throat cancer are alcohol use, tobacco use, and infection with the HPV (human papillomavirus), coffee drinking seems to be something of a deterrent.

Your body needs certain enzymes and nutrients, especially folate and B vitamins, to carry out the methylation cycle. Oxidative stress and inflammation are capable of interfering with the process. This means that a healthy diet and lifestyle are both key for optimizing methylation.

Problems start arising when methylation is not optimized, meaning, it's happening slower than it should be (or the opposite: it's happening too fast!). In general, the methylation cycle slows down when it doesn't have enough methyl-supportive nutrients and speeds up when it has too many.

Lifestyle changes can have an impact on methylation patterns. For example, smoking can decrease methylation on a gene called AHRR . But quitting smoking has been shown to increase methylation of AHRR, which means that former smokers can return to the same AHRR gene expression as non-smokers over time.

The two most important nutrients in methylation pathways are B12 and folate, but other nutrients such as methionine, cysteine, taurine, DHA, zinc, magnesium, potassium, riboflavin, niacin, pyridoxine, betaine, choline, and sulfur also play a role (10). Inadequate intake of any of these nutrients can impair methylation.