Strengths and Limitations of Methylated Vitamins (2024)

Strengths and Limitations of Methylated Vitamins (1)

Written By:
Dr. Ramneek Bhogal

Strengths and Limitations of Methylated Vitamins (2)

“Take your vitamins” is something we’ve been told since we were kids. And for good reason.

Vitamins contain methyl groups, which affect a wide range of bodily functions from energy levels to hormone pathways and the immune system.

B-vitamins like folate provide a large portion of methyl groups, as does methionine. All these nutrients share the need to be broken down and processed by the body at the chemical level through a process called methylation, which adds three hydrogen and one carbon atom to the compound and prepares it to be utilized in a number of systems. Patients of functional medicine practitioners can experience benefits to a number of bodily systems through a vitamin regimen.

Strengths and Limitations of Methylated Vitamins (3)

Systemwide Benefits and Absorption

The hormone system, metabolism, and the circulatory system are impacted by methylation.

Methyl-related nutrients are tied to stress, detoxification, inflammation response, energy production, and hom*ocysteine production. This is why a methyl B vitamin complex is a regular part of many people’s daily supplement routine.

Additionally, vitamins in these groups act as facilitators and help most other systems in the body perform their duties efficiently. Since methyl-related vitamins have a direct impact on the metabolism as well as the detoxification of hormonal pathways, they also aid with the absorption and impact of any nutrient that is taken alongside it, even beyond methyl groups.

Yet, there’s more to absorbing nutrients than just popping a pill or chewing a gummy and digesting. When these vitamins are ingested through the food we eat, they’re not ready to be absorbed. They are in an inactive state.

The body needs to prepare them through the methylation process. This process changes vitamins into their methylated, or active, state, and that’s when the body can then use them to keep all its systems running properly.

However, around 30% of the population has what’s called a MTHFR mutation, which causes the body to struggle with the methylation process. In these cases, taking an unmethylated vitamin won’t do much good.

Fortunately, medical technology has progressed far enough to offer methylated vitamins. In fact, for most professional level supplement providers, methylated vitamins have been the standard for some time, and the retail space has caught up. This is good news, and not only for those with the MTHFR mutation. Everyone can benefit from the active state of methylated vitamins.

The Power of Active Vitamins

Think of methylated vitamins like buying a new bike.

You have two options: either you purchase the pieces and put it together yourself, or you can buy a pre-assembled bike that’s ready-to-ride. If want to go on a bike ride right now, then you want the pre-assembled bike that you can use today.

Patients with the MTHFR mutation need the ready-to-ride bike, as they are unable to assemble one themselves. The ready-to-ride option will put everybody else on the road faster, as well.

Methylated vitamins work in a similar fashion. They are already in their active state, so the rate at which they can be absorbed by the body is much greater than unmethylated vitamins, which means the body can utilize those nutrients faster.

It’s important to remember that vitamins are not energy drinks though. They shouldn’t be taken with the same energy-boost-then-crash expectations. As with all supplements, there are some caveats to the benefits of methylated vitamins. These should be taken into consideration before adding them to a patient’s regimen.

The Limits of Methylated Vitamins

The benefits of vitamins in the methyl groups are proven and well documented.

They help provide energy, balance hormones, limit hom*ocysteine levels, and even help alleviate a cloudy mind and depression. Yet, any supplement can only be so effective when it’s not paired with a healthy lifestyle and diet.

Eating dark green vegetables like brussel sprouts and broccoli is a great way to get natural folate. Influencing the microbiome with healthy flora will improve the absorption of B vitamins and methylated folic acid. The more you eat, the better your body gets at absorption.

Controlling your environment also goes a long way to help the effectiveness of supplements. This means reducing overall stress, controlling alcohol consumption, avoiding smoking, and eliminating other toxins in the patient’s environment. Maintaining a healthy amount of proteins and amino acids in the body will support the methyl groups as well.

Without enough sleep or exercise, every system in the body is affected, and the absorption of methyl-related nutrients is no exception. It won’t provide a solution to feeling energy deprived on its own. That’s why taking an overall holistic approach when considering the impact of supplements is vital.

Methylated Vitamins Can Help You, and You Can Help Them

Methyl groups have a hand in nearly every bodily function, from brain chemistry to the nervous system.

When taken as a dietary supplement in their active, methylated state, the body can fortify its functions without having to methylate on its own. For these reasons, a methyl b complex supplement can give anyone a health boost. But like all supplements, a methylated vitamin is no match for an unhealthy diet and poor environment, which is why a 360 degree approach must be taken for patients to feel their best.

Strengths and Limitations of Methylated Vitamins (4)

Nutritional Supplements , Supplements , Energy

Strengths and Limitations of Methylated Vitamins (2024)

FAQs

What are the benefits of methylated vitamins? ›

The benefits of vitamins in the methyl groups are proven and well documented. They help provide energy, balance hormones, limit hom*ocysteine levels, and even help alleviate a cloudy mind and depression. Yet, any supplement can only be so effective when it's not paired with a healthy lifestyle and diet.

Who should not take methylated vitamins? ›

You should not use l-methylfolate if you are allergic to it. To make sure l-methylfolate is safe for you, tell your doctor if you have: seizures or epilepsy; a history of vitamin B12 deficiency or pernicious anemia; or.

What happens when you start taking methylated vitamins? ›

These methylated forms have been shown to improve folate and B12 levels more effectively than synthetic folic acid and cyanocobalamin. Remember, each person's dosage of b complex vitamins will vary, so it's a good idea to talk to a health practitioner before starting a new supplement regime.

What are the benefits of methylfolate? ›

L-methylfolate is a form of folate, or vitamin B9, that can help regulate serotonin and dopamine levels. Because these chemicals affect mood, some people believe taking l-methylfolate may help with depression.

Is methylation good or bad? ›

Methylation reactions are fundamental to human metabolism. Examples include cellular detoxification, neurotransmitter synthesis, cell growth, tissue repair and gene expression. Technically, methylation is neither inherently good nor bad – it is simply a process.

How long does it take for methylated vitamins to work? ›

It can take between 1 to 4 weeks for L-methylfolate to begin working; however, this depends on many factors such as metabolic function, age, symptom severity, and more. It could take several months for it to become fully effective.

Who should not take methylfolate? ›

This medication contains L-methylfolate. Do not take Deplin if you are allergic to L-methylfolate or any ingredients contained in this drug. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Who needs methylated vitamins? ›

Methylation is absolutely crucial to the growth of new tissue, so it is vital for fertility, maintaining a healthy pregnancy and supporting foetal growth. Your need for nutrients, (folic acid from folate in particular) increases exponentially during pregnancy.

What is the best methylated vitamin? ›

Best Overall: Methyl-Life® Chewable Methylated Multivitamin

It contains a dose of methylfolate and other nutrients involved in the methylation process, including active B12 as Hydroxocobalamin and active B6 as P-5-P (Pyridoxal-5-Phosphate).

What does methylfolate do to the brain? ›

Methylfolate crosses the blood brain barrier and is a cofactor required for the complete synthesis of serotonin, norepinephrine, and dopamine in the brain.

Who needs methylfolate? ›

People who suffer from depression, anxiety or bipolar disorder may be helped by taking methylfolate supplements. The higher levels of hom*ocysteine typically experienced by people who don't have enough methylfolate can also affect memory, with the possibility of dementia and Alzheimer's disease being linked with this.

Does methylated folate help anxiety? ›

Methylfolate is used by the body in the production of serotonin, dopamine, and norepinephrine, which are involved in the regulation of mood and anxiety, and the mechanisms of actions of antidepressants.

Are methylated vitamins better for you? ›

That is why in some cases the biologically active form of folate, called 5-methyltetrahydrofolate (5-MTHF), is recommended for certain individuals instead of folic acid. This is the only case where the methylated form of a vitamin seems to give benefits compared to its non-methylated form.

How do you know if you need methylated vitamins? ›

Some common signs and symptoms which can indicate methylation support is needed: Infertility or pregnancy-related complications- methylation helps in promoting foetal growth and maintaining a healthy pregnancy. Multiple miscarriages are a big red flag that there is a problem with methylation.

What are the symptoms of poor methylation? ›

Impaired methylation results in decreased production of dopamine. The altered dopamine levels ultimately lead to altered levels of the other neurotransmitters. As a result, these individuals lack focus, concentration, short-term memory, organization, emotional stability, good sleep hygiene, and hormone regulation.

What vitamins should be methylated? ›

Methyl nutrients include folates (vitamin B9), riboflavin (vitamin B2), cobalamin (vitamin B12), pyridoxine (vitamin B6) and choline (vitamin B4), as well as methionine and betaine. These substances play the role of both substrates and cofactors in transformations related to one-carbon metabolism.

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