L-Methylfolate Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD (2024)

Uses

Folic acid is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.Folic acid supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of folic acid either through their diet or supplements to prevent infant spinal cord birth defects.

How to use L-Methylfolate

Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.

Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.

If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away.

Side Effects

Folic acid usually has very few side effects. If you have any unusual effects from taking this product, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this product, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this product do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this product, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this product, tell your doctor or pharmacist your medical history, especially of: vitamin B-12 deficiency (pernicious anemia).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Folic acid is safe to take during pregnancy when used as directed. It is included in prenatal vitamin products. Certain spinal cord birth defects may be prevented by taking adequate amounts of folic acid during pregnancy. Consult your doctor for more details.

Folic acid passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Does L-Methylfolate interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: mental/mood changes.

Notes

Do not share this medication with others.

Lab and/or medical tests (such as complete blood count, folate blood level, vitamin B-12 blood level) should be done while you are taking this product. Keep all medical and lab appointments. Consult your doctor for more details.

Folate is naturally found in leafy green vegetables, organ meats (liver, kidney), citrus fruits, and other foods. Folic acid is added to enriched grain products such as bread, pasta, and cereal. Consult your doctor or dietician for a diet plan rich in folate/folic acid.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

L-Methylfolate Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD (2024)

FAQs

What drugs interact with methylfolate? ›

L-methylfolate may interact with the following drugs:
  • carbamazepine.
  • fosphenytoin.
  • phenobarbital.
  • phenytoin.
  • primidone.
  • pyrimethamine.
  • raltitrexed.
  • sulfasalazine.

Who should not take l-methylfolate? ›

You should not use l-methylfolate if you are allergic to it. To make sure l-methylfolate is safe for you, tell your doctor if you have: seizures or epilepsy; a history of vitamin B12 deficiency or pernicious anemia; or.

What is the risk of methylfolate? ›

Many people using this product do not have serious side effects. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

Can you take vitamin D and methylfolate together? ›

Interactions between your drugs

No interactions were found between l-methylfolate and Vitamin D3.

Does L-Methylfolate interact with anything? ›

Some products that may interact with this medication include: chloramphenicol, certain anti-seizure drugs (such as phenytoin), methyldopa.

What medications should be avoided with MTHFR? ›

Drugs to avoid with MTHFR Mutation
  • Antacids (depletes B12)
  • Proton Pump Inhibitors (depletes B12)
  • Cholestyramine (depletes B12 & folate)
  • Cholestipol (depletes B12 & folate)
  • Methotrexate (inhibits DHFR: Folate->THF)
  • Nitrous Oxide (Inhibits MTR – Methionine Synthase)
Apr 13, 2017

Can L-methylfolate cause high blood pressure? ›

L‐methylfolate is a natural food folate with no upper limit safety concerns, unlike folic acid, with the dual benefit of lowering blood pressure.

What drugs should not be taken with folic acid? ›

Taking folic acid with fosphenytoin (Cerebyx), phenytoin (Dilantin, Phenytek) or primidone (Mysoline) might decrease the drug's concentration in your blood. Barbiturates. Taking folic acid with a drug that acts as a central nervous system depressant (barbiturate) might decrease the drug's effectiveness.

Should you take B12 and methylfolate together? ›

Interactions between your drugs

No interactions were found between l-methylfolate and Vitamin B12.

How does methylfolate make you feel? ›

There are side-effects from methylfolate, but they are mild and infrequent. These include a sense of discomfort, nausea, rash and allergy. Reducing the dose might lessen side-effects. There are also concerns that long-term use might increase certain cancers and cardiovascular disease, but the data are not robust.

Can methylfolate cause anger? ›

These three cases illustrate the rare but possible adverse effects of agitation, irritability and possible onset of hypomania with adjunctive L-methylfolate.

What does methylfolate do for the brain? ›

Methylfolate crosses the blood brain barrier and is a cofactor required for the complete synthesis of serotonin, norepinephrine, and dopamine in the brain. Supplementation with L-methylfolate in addition to SSRIs or SNRIs shows symptom reduction in MDD, and may be an effective monotherapy in MDD.

Can I take methylfolate with magnesium? ›

Interactions between your drugs

No interactions were found between L-Methylfolate Forte and magnesium oxide.

What are the symptoms of a methylfolate deficiency? ›

Deficiency of folate may be asymptomatic or present with the symptoms of anemia, diarrhea, loss of appetite, and weight loss. Additional signs are weakness, sore tongue, headaches, heart palpitations, irritability, and behavioral disorders.

What is the best form of L-Methylfolate? ›

The most biologically active forms of methylfolate are (6S)-5-methyltetrahydrofolate or (6S)-5-MTHF, also known as “L” forms. These may be labeled as: (6S)-5-methyltetrahydrofolic acid, calcium salt, also labeled as L-methylfolate. (6S)-5-methyltetrahydrofolic acid, monosodium salt.

Is methylfolate safe for everyone? ›

In some people, l-methylfolate can cause side effects, such as anxiety or digestive symptoms. It is also unsuitable for those who take certain medications or have some health conditions.

Can I take methylfolate with antidepressants? ›

LMF is an approved nutritional adjunctive antidepressant therapy that increases central neurotransmitter levels and thereby improves the effectiveness of antidepressant therapy. LMF can increase clinical response when used adjunctively in patients with major depressive disorder (MDD) and who are SSRI-resistant.

Which class of drugs interfere with folate folic acid metabolism? ›

Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B9).

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