Can patients with cystic fibrosis benefit from medical cannabis treatment? (2024)

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The researchers also suggested that “…potential benefits from THC treatment, in addition to appetite stimulation, will include antiemetic, bronchodilating, anti-inflammatory, anti-diarrheal and hypo-algesic effects.”

A 2020 survey on CF patients using medical cannabis noted that those who self-reported use were mainly using it for pain and stress alleviation (8). They reported that “28 out of 31 found marijuana to be a great deal effective for their symptoms, and 21 of the 31 rated marijuana ” very important to their health.”

The non-psychotropic compound CBD (cannabidiol) could also help relieve cystic fibrosis symptoms since the cannabinoid may help to minimize tissue damage by exerting its anti-inflammatory, anti-anxiety, and antidepressant effects.

A study on the “Antioxidative and Anti-Inflammatory Properties of Cannabidiol” that was published in the journal Antioxidants (Basel) in 2020 found that CBD reduces the levels of pro-inflammatory cytokines, inhibits T cell proliferation, induces T cell apoptosis and reduces migration and adhesion of immune cells (2).

The Role of the Endocannabinoid System in Treating Cystic Fibrosis

Cystic fibrosis has a strong connection with many of our body’s integral systems, including the endocannabinoid system (ECS). The ECS produces cannabinoids and uses them to manage a whole host of functions that might influence the quality of life of people with CF, including appetite, nausea, inflammation, pain, and mood regulation.

The effects of the ECS can be experienced when a cannabinoid attaches to CB1 and CB2 receptors found within the system. These receptors can bind to the body’s endocannabinoids and the plant’s phytocannabinoids. The CB1 and CB2 receptors have been found in the immune cells and the gut, among virtually every organ system.

When cannabinoid receptors are activated, the surrounding tissue and nerves get a spa day. CB1 receptors have been identified in the vagus nerve, which transfers signals between the brain and the gut. Inflammation and other types of immune functions are impacted by cannabinoid receptor stimulation.

A study published in the Journal of Cannabis Therapeutics, titled “Cannabinoids and Cystic Fibrosis in February 2002”, found that CF patients display lower levels of endocannabinoids (4). They proposed that the CFTR may be involved in endocannabinoid synthesis as it is in fatty acid balance. Elevating these therapeutic compounds’ levels through medical marijuana use could promote symptomatic relief in cystic fibrosis patients.

This thought is also echoed in Dr. E.B Russo’s article on Clinical Endocannabinoid Deficiency (CED) regarding CF and many other disorders not yet fully managed by today’s medicine (7).

What Preparations of Cannabis are Best for Cystic Fibrosis?

You are not limited to smoking a joint or vaping (although these two methods of consumption offer fast relief) when you use medical cannabis for cystic fibrosis. The 2020 BMC survey on CF patients reported, “The most used forms were edible and vaporized (8).” However, harsh inhalational routes like smoking should be avoided. Any method or treatment should be discussed with your provider first.

However, myriad product options and preparations are available, each of which has benefits.

Listed below are some recommended choices for CF patients:

• Edibles — Chow down on a cannabis-infused edible for accurate dosing and effects that could last for 5-8 hours.
• Pills, capsules, and tablets — More discreet and convenient, this category of cannabis preparations for CF are ideal for controlled dosing while on the move.
• Powder Cannabis — Scientists have figured out how to make cannabinoids water-soluble, meaning that you can drink your medicine and experience improved bioavailability.
• Transdermal Patches —When you wear topical, transdermal patches, cannabis compounds get absorbed via the bloodstream after penetrating the skin.
• Tinctures — Another way cannabis can be used for CF is oil tinctures, which can be dropped beneath the tongue for rapid bloodstream absorption within minutes and better bioavailability than edibles.

Talk to Your Doctor About Medical Cannabis

To gain a broader understanding of the type of cystic fibrosis you are dealing with and to pinpoint any potential complications, your doctor or healthcare practitioner may conduct a series of tests and medical examinations. Once you’ve received a diagnosis, you can discuss medical cannabis use with a doctor.

Refrain from using cannabis as a substitute for other types of doctor-prescribed medications that relieve chronic pain, infections, and improve lung function in cases of CF. Instead, use it alongside conventional medicine (with a doctor’s approval). Be aware of potential side effects that might occur if you consume cannabis with other meds too.

Complementary Treatments Worth Discussing with Your Doctor

The diagnostic and therapeutic disciplines used alongside conventional medicine are known as complementary therapies. Examples of complementary medicine include massage, meditation, biofeedback, tai chi, reiki, music therapy, guided imagery and dietary supplements.

Remember that if you consult complementary practitioners (aside from osteopaths, naturopaths, and chiropractors), most can legally practice without licensing but with some previous training. They should have finished some further education or training course in their chosen discipline.

Integrating cannabis into your routine may also be a valuable decision. Connecticut is one state that permits the use of medical cannabis for cystic fibrosis, with CF being added to the list of qualifying conditions in 2016 (6).

You must continue using any medication(s) prescribed by your doctor and inform your doctor about your desire to medicate with cannabis.

Note: The content on this page is for informational purposes only and is not intended to be professional medical advice. Do not attempt to self-diagnose or prescribe treatment based on the information provided. Always consult a physician before deciding on the treatment of a medical condition.

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